This consanguine incestuous relationship is the most influential in terms of works of art be it literature, television or films. This includes instances of incest between same sex siblings, siblings of different sex, twins and cousins.
The latest example is A Game of Thrones. Published in 1996, A Game of Thrones is the first volume of the epic fantasy series Song of Fire and Ice. The series has been written by American Novelist and screenwriter George R.R. Martin. It has been adapted into a popular television series on HBO. The two siblings involved in an incestuous relationship are Queen Cersei and her biological twin Jamie.